Hypersensitivity. Heart failure, Morgagni-Adams-Stokes syndrome, atrioventricular block II-III century., Sinus block, bradycardia, kidney disease, liver, cachexia, porphyria. Pregnancy and lactation.
Be wary . Used with caution in patients suffering from alcoholism, diabetes mellitus, systemic lupus erythematosus, with hyperthermia.
Dosage and administration . administered orally during or immediately after a meal. The single dose for adults: ½ – 1 tablet. Take 2-3 times a day.According to the testimony of trenbolone acetate results the daily dose was increased to 3-4 tablets. Higher doses for adults: single – 3 tablets daily – 8 tablets. Use in children: up to 5 years – ¼ pill 2 times per day, 5-8 years – ¼ tablet 3-4 times a day, over 8 years – by ½-1 tablet 2 times a day.
Side effect . From the nervous system: tremor, ataxia, dysarthria, diplopia, irritability, insomnia, dizziness. From the senses: nystagmus, pain in the eyes. From the digestive redundant system: gastritis, loss of appetite, nausea, vomiting, gastralgia, constipation . From the side of hematopoiesis: leukopenia, aplastic anemia, megaloblastic, vitamin B12 deficiency anemia, agranulocytosis, lymphadenopathy. Allergic reactions : skin rash, fever, erythema multiforme exudative and toksikodermiya. Other: polyarthritis, hirsutism, gingival hyperplasia, weight loss, change connective tissue (coarsening of facial features, Dupuytren’s contracture); long-term use (2-5 months) -. breach of calcium-phosphorus metabolism, latent osteopathy, dyspnea is a sudden cancellation of the drug may be a withdrawal. When expressed adverse events gradually reduce the dose or stop the use of phenytoin.
Overdose . In the event of an overdose of the drug may increase the toxic side effects. Because no antidote exists, we recommend the use of activated charcoal, laxative drugs and symptomatic therapy.
Prolonged use may be manifestations of the syndrome of hypersensitivity to the drug and marked depression of the central nervous system, which requires discontinuation of the drug.
The interaction with other drugs .
Enhances hepatotoxicity and prolong the effect of paracetamol.
Increases chlorpromazine toxicity and other derivatives of phenothiazine, reserpine, sulfonamides..
Amiodarone increases the concentration of phenytoin in blood.
Antacids containing salts Al + 3, Mg + 2 and Ca 2+; preparations for parenteral nutrition, sucralfate reduce bioavailability; calcium sulfate reduces the absorption by 20%.
Anticoagulants indirect, chloramphenicol, cimetidine, disulfiram, antiviral vaccine, isoniazid, methylphenidate, phenylbutazone, ranitidine, salicylates, sulfonamides, fluconazole, ketoconazole, miconazole reduce metabolism, increase the active concentration in the blood and reinforce anticonvulsant effect .
Anticonvulsants (succinimide, carbamazepine) estrogensoderzhaschie contraceptives, steroids, mineralokortikosteroidy, adrenocorticotropic hormone, cyclosporin, dacarbazine, glycosides digitalis dieopiramid, doxycycline, estrogens, furosemide, levodopa mikseletin, quinidine, methadone, praziquantel, trenbolone acetate results vitamin D, aminophylline, caffeine , okstrifillin theophylline metabolized more rapidly (due to the induction of hepatic microsomal enzymes), thereby reducing their concentration in the blood.
Tritsikpicheskie antidepressants, bupropion, clozapine, haloperidol, loxapine, maprotiline, molindone, monoamine oxidase inhibitors, phenothiazines, pimozide, thioxanthenes, sulfinpyrazone reduce the anticonvulsant effect (so dose adjustment of phenytoin may be required).
phenytoin may raise blood glucose levels, and therefore reduces the effect of insulin and oral hypoglycemic agents; violates the complexation of levothyroxine from plasma proteins by 15-25%.
Barbiturates, primidone, fluoxetine, folic acid may alter the concentration in the blood (there is a need to be monitored).
Diazoxide reduces hyperglycemic activity of phenytoin.
Dopamine may promote arrhythmias and lower blood pressure.
Inflyuran, halothane, methoxyflurane – the use of phenytoin before anesthesia may increase the metabolism of the anesthetic and the risk of hepatotoxicity and nephrotoxicity.
lidocaine and beta-blockers in combination with phenytoin may depress cardiac function; while significantly increasing metabolism of lidocaine.
Omeprazole inhibiting cytochrome P450 reduces the metabolism of phenytoin.
Rifampin stimulates metabolism in the liver.
trazodone increases in blood concentration.
valproic acid and phenytoin, inhibit the metabolism of each other, which can lead to increased hepatotoxicity.
phenobarbital and carbamazepine increase elimination of (mutually) phenytoin.
Isoniazid, acetylsalicylic acid, chloramphenicol and disulfiram inhibit metabolism, increasing the side effects.
During treatment requires careful selection of doses (for epilepsy, the concentration in the blood for 7-10 days of treatment), as well as an increase in the dose may be accompanied by a disproportionate increase in plasma levels.
In the period of treatment is necessary to control the content of Ca2 + and phosphorus in the blood serum.
when expressed adverse events, dose reduce or stop treatment.
Patients with impaired liver function, and the elderly require correction dosing regimen.
phenytoin concentration is increased in acute alcohol intoxication, in chronic – is reduced. In the period of treatment should refrain from driving motor vehicles and activities potentially hazardous activities that require high concentration and trenbolone acetate results psychomotor speed reactions.
Product form . Pills. 10 tablets in contour bezgyachakova packaging. 1 or 2 circuits Valium package with the instruction on the medical application in a pile of cardboard.
Shelf life . 4 years. Do not use end date. where to buy anabolic steroids online buy nandrolone decanoate anabolic steroids online uk